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2-year neurodevelopmental and respiratory outcomes of infants with bronchopulmonary dysplasia requiring positive pressure support at 36 weeks postmenstrual age

Presented as a poster at the Neonatal Society 2016 Summer Meeting.

Bhayat S1, Belani P1, Somisetty S1, Satodia P2,3, Gowda H1

1 Luton and Dunstable University Hospital, UK
2 University Hospital of Coventry and Warwickshire NHS Trust, Coventry, UK
3 University of Warwick, UK

Background: BPD is associated with significant morbidities in premature infants. The aim of this study is to look at neurodevelopment and respiratory outcomes at 2 years of age of preterm infants requiring positive pressure support (PPS) at 36 weeks PMA.

Methods: This retrospective observational case-control study was conducted over a 3-year period (01/02/2010-31/12/2012) in a level 3 NICU. Preterm infants requiring PPS (Ventilation, BiPAP, CPAP or High flow) at 36 weeks PMA were included (Group A). Controls (Group B) were infants with BPD (Oxygen requirement at 36 weeks PMA) on low flow oxygen, matched to cases according to gestation. Neurodevelopmental outcome was assessed by Bayley’s III neurodevelopment assessment at 2 years; and respiratory outcomes by looking into readmissions for respiratory illness.

Results: Total 2478 infants were admitted to NICU between 01/01/2010 to 31/01/2012. 418 (16.8%) were born below 32 weeks gestation, of which 144 (38%) had BPD. 14 infants were included in both groups. There was no statistically significant difference in gestational age(26+4), weights (A:755g,B:790g, p=0.802), incidence of PDA’s (treated 11vs7, p=0.2365) and grade IIIIV intraventricular haemorrhage (2vs0, p=0.4815 ). All 14 infants requiring PPS were on CPAP at 36 weeks PMA. Neurodevelopmental outcomes are detailed in Graph1. Infants in PPS group had average 2.94 readmissions to the paediatric unit within their first 2 years of life for respiratory causes versus 2.07 to the control group (t-test p=0.66).

2-year neurodevelopmental and respiratory outcomes of infants with bronchopulmonary dysplasia requiring positive pressure support at 36 weeks postmenstrual age

Conclusion: There is an association between poor neurodevelopmental outcomes in infants requiring PPS at 36weeks PMA. However, there is no statistically difference in number readmissions for respiratory causes.

Corresponding author: sadaf.bhayat@gmail.com

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