Share on facebook
Share on twitter
Share on linkedin

Preterm Infant Brain Pathology Revealed in Individuals by Voxel Ranking against a Normal Term Atlas

Presented at the Neonatal Society 2014 Spring Meeting.

Dickie DA1, Job D1, Sparrow S2, Piyasena C3, Wilkinson G4, Wardlaw J1, Boardman JP2

1 Centre for Clinical Brain Sciences, University of Edinburgh, UK
2 MRC / University of Edinburgh Centre for Reproductive Health, UK
3 Centre for Cardiovascular Science, University of Edinburgh, UK
4 Royal Hospital for Sick Children, NHS Lothian, UK

Background: Preterm birth is associated with alterations in brain structure detected by group wise comparisons with term controls using voxel based null hypothesis significance testing, e.g. t-tests. However, this approach does not describe how ‘normal’ an individual subject is. Percentile rank atlases have been developed to measure the ‘normality’ of individual subjects. Hypothesis: voxel-based ranking against an atlas created from term controls will detect alterations in individual preterm infants.

Methods: Subjects: 43 preterm VLBW infants (postmenstrual age [PMA] at birth <32 weeks’ gestation; birth weight <1500g) were recruited with approval from the NHS Research Ethics Service. Image acquisition: Siemens Verio 3T system was used to acquire T1 weighted MP-RAGE images in the sagittal plane with 1x1x1mm resolution; 13 subjects were excluded due to severe motion artefact. Processing: semi-automatic brain extraction and spatial and intensity normalisation to the Montreal Neurological Institute 36-44 weeks’ PMA normal infant atlas. Deviation from normal was calculated by % difference in each voxel: (Ui-Xij/Ui)x100, where Ui is voxel i in the atlas and Xij is voxel i in subject j. Funding body: Theirworld.

Preterm Infant Brain Pathology Revealed in Individuals by Voxel Ranking against a Normal Term Atlas

Results: The output for each subject is a fully ranked image (i) and an abnormal mask visualised in atlas space at a specified threshold (ii). In the example: (i) green regions show where the preterm infant voxel value = atlas, and yellow-red is where preterm voxel value < atlas; (ii) regions where the individual voxel is <12.5th percentile with respect to atlas. Lower voxel values indicate CSF where tissue is present in controls. Voxel-based ranking detected lateral ventricle enlargement in 30/30 preterms, with 37% showing localisation of enlargement to the temporal horns of the lateral ventricles.

Conclusion: Voxel based ranking against a term control neonatal atlas detects regional structural variation associated with preterm birth at the level of the individual. Our method and data will be made available online: http://www.sinapse.ac.uk/research-resources/brains-project

Corresponding author: ddickie1@staffmail.ed.ac.uk

Avants et al Med Image Anal 2008
Boardman et al NeuroImage 2006
Dickie et al PLoS ONE 2013
Fonov et al Neuroimage 2009

More to explorer

2020 Spring Meeting

The Spring Meeting of the Neonatal Society has been cancelled due to COVID-19 Dear member, After careful consideration we have decided to

2019 Autumn Meeting

7th November 2019 The Royal Society of Medicine, London 9:30 – 17:30 with a drinks Reception at 18:00 Open to all professionals

2019 Summer Meeting

60th anniversary celebration This special meeting marked the 60th anniversary of the founding of the Neonatal Society. A series of keynote lectures

Search by category
Scroll to Top

We use cookies to ensure that we give you the best possible experience on our website. By continuing to browse the site you are agreeing to the use of cookies from The Neonatal Society.