Share on facebook
Share on twitter
Share on linkedin

Do serum troponin I concentrations correlate with severity of HIE?

Presented at the Neonatal Society 2010 Summer Meeting.

Shastri AT, Samarasekara S, Clarke P

Neonatal Intensive Care Unit, Norfolk & Norwich University Hospital, UK

Background: Myocardial dysfunction occurs frequently in babies with perinatal asphyxia. Cardiac troponin I (cTnI) is a surrogate marker of myocardial dysfunction in adults but there are few data in neonates (1,2). We aimed to compare serum cTnI concentrations with clinical severity of encephalopathy in asphyxiated neonates. 

Methods: Retrospective review of cTnI concentrations in neonates admitted to our neonatal unit with hypoxic ischaemic encephalopathy (HIE) in the 63-month period January 2005 to March 2010. We compared serum cTnI concentrations measured in the first 48 hours postnatal with clinical grade of HIE (Sarnat-Sarnat classification), and also with duration of inotropic support. Ethics approval was not required for this study.

Results: 42 neonates were admitted with HIE in the study period. Median (range) gestational age and birth weight were 38.8 weeks (27 – 42 weeks) and 3012 g (1080-4620 g). The table shows their cTnI concentrations and duration of inotropic support according to HIE grade:

Do serum troponin I concentrations correlate with severity of HIE?

 Data are median (range)

Conclusion: Cardiac troponin I concentrations correlate strongly with clinical grade of HIE and with duration of inotropic support in asphyxiated neonates. These data suggest that early cTnI concentrations provide a useful marker of the severity of myocardial dysfunction in asphyxiated neonates. 

1. Türker G, et al. Biol Neonate 2004; 86:131-137.
2. Trevisanuto D, et al. Biol Neonate 2006; 89:190-193.

More to explorer

2020 Spring Meeting

The Spring Meeting of the Neonatal Society has been cancelled due to COVID-19 Dear member, After careful consideration we have decided to

2019 Autumn Meeting

7th November 2019 The Royal Society of Medicine, London 9:30 – 17:30 with a drinks Reception at 18:00 Open to all professionals

2019 Summer Meeting

60th anniversary celebration This special meeting marked the 60th anniversary of the founding of the Neonatal Society. A series of keynote lectures

Search by category
Scroll to Top

We use cookies to ensure that we give you the best possible experience on our website. By continuing to browse the site you are agreeing to the use of cookies from The Neonatal Society.